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MYP_106421
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Basic Information
CGm
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C90H153N35O23S4
Standard
Sequence
GCRRLCYKQRCVTYCRGR
Physicochemical Analysis
2221.66 Da
9.93
5.72
5.45
0.3176
-0.89
0.47
-0.57
40.78
37.78
0.1111
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
997.32
-11.69
43.0
33.0
74.0
152.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0293127 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
2-15; 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Hemolytic
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0357435 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
2-15; 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic
K-562
12
CC50
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0363831 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human erythrocytes
64 μM
Hemolysis
PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0376480 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
2-15; 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Hemolytic
human red blood cells
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0379106 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
2-15; 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic
MCF-7
2
CC50
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
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