Peptide Database

Peptide NameCGm

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC90H153N35O23S4

DescriptionStandard

        GCRRLCYKQRCVTYCRGR
    

Molecular Weight2221.66 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3176

GRAVY Index-0.89

Hydrophobic Moment 0.47

Boman Index-0.57

Instability Index40.78

Aliphatic Index 37.78

Aromaticity 0.1111

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 997.32

LogP -11.69

H-bond Donors 43.0

H-bond Acceptors 33.0

Rotatable Bonds 74.0

Heavy Atoms 152.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0293127 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic disulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide2-15; 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Hemolytic

Targethuman red blood cells

Activity50 %

MethodHemolysis concentration-response assay

RECORD: Rec_0357435 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic disulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide2-15; 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic

TargetK-562 leukemia cells

Activity2.7±0.1 μM

MethodCC50

RECORD: Rec_0363831 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic disulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-15; 6-11

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity50 %

MethodHemolysis at 100 μM

RECORD: Rec_0376480 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic disulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide2-15; 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Hemolytic

Targethuman red blood cells

Activity50 %

MethodHemolysis at 100 μM

RECORD: Rec_0379106 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic disulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide2-15; 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic

TargetMCF-7 breast cancer cells

Activity15.3±1.4 μM

MethodCC50

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