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MYP_106175
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Basic Information
T-252
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Standard
35 amino acids
C168H274N46O53
Standard
Sequence
PDAVYLHRIDLGPPISLERLDVGTNLGNAIAKLED
Physicochemical Analysis
3786.25 Da
4.64
-2.94
-3.06
-0.0841
-0.08
0.54
0.08
2.41
125.43
0.0286
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1570.32
-13.68
53.0
51.0
123.0
267.0
5.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035503 VERIFIED: YES
Provenance & Taxonomy
Measles morbillivirus [Virus]
Virus-derived peptide
11234;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor Cytoprotective
Measles virus (Fusion); HEp2
100 μM
EC50
PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
RECORD: Rec_0062775 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Respiratory syncytial virus fusion-inhibitory peptide
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Anti-RSV Fusion inhibitor
HIV
PaperHuman respiratory syncytial virus peptides with antifusogenic and antiviral activities Evidence URLhttps://patents.google.com/patent/US6228983B1/en PatentUS 6228983 B1
RECORD: Rec_0160892 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
HIV gp41 fusion inhibitor
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV
HIV
PaperLong-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides Evidence URLhttps://patents.google.com/patent/US7582301B1/en PatentUS 7582301 B1
RECORD: Rec_0256873 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Evidence URLhttps://patents.google.com/patent/US6228983B1/en PatentUS 6228983 B1
RECORD: Rec_0337024 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-MeV Entry inhibition
Measles virus (MV) | HEp-2 cells
26.41 μM
EC50
Mammalian: >20 h; Yeast: >20 h; E. coli: ?
PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91. | DOI:10.1073/pnas.93.5.2186 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
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