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MYP_106110
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Basic Information
Gaegurin-2 (Gaegurin 2; GGN2; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C142H254N40O44S3
Standard
Sequence
GIMSIVKDVAKNAAKEAAKGALSTLSCKLAKTC
Physicochemical Analysis
3321.97 Da
9.51
3.74
3.50
0.1133
0.30
0.67
0.08
19.15
97.88
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1369.48
-15.80
50.0
51.0
118.0
229.0
0.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0252813 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Candida albicans
150 μg/mL
MIC
PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0295514 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Eshchericia coli
75 μg/mL
MIC
PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0313717 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Serratia marcescens
200 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa. Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. doi: 10.1006/bbrc.1994.2757. PMID: 7999137. PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0315737 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Proteus mirabilis
200 μg/mL
MIC
PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0317846 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antiparasitic
Bacillus subtilis
10 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa.
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