Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length109 amino acids

Chemical FormulaC550H892N144O153S6

DescriptionStandard

        MVILEKKLANVKLPDISGDFDVKVVGKVHYELSSLDLRNFHLPHSRISLLPNEGPQVSISNAFADVRGNWKVKKSLMYVPDSLLPCSDSVIFLLSLVSGQMLLCPLQMR
    

Molecular Weight12162.23 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)1.75

Net Charge (pH 7.4) 1.33

Charge Density (pH 7.0) 0.0160

GRAVY Index0.20

Hydrophobic Moment 0.54

Boman Index0.12

Instability Index28.58

Aliphatic Index 116.97

Aromaticity 0.0642

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4723.35

LogP -38.11

H-bond Donors 162.0

H-bond Acceptors 164.0

Rotatable Bonds 405.0

Heavy Atoms 853.0

Ring Count 18.0

Amide Bonds 116.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205348 VERIFIED: NO

Provenance & Taxonomy

OrganismLimosa lapponica baueri [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence