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MYP_106084
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Basic Information
Signiferin-1
Antimicrobial
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Standard
10 amino acids
C55H91N13O12S2
Standard
Sequence
RLCIPYIIPC
Physicochemical Analysis
1190.52 Da
8.06
0.74
0.51
0.0739
1.33
0.26
0.38
-4.30
156.00
0.1000
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
389.77
0.03
15.0
15.0
33.0
82.0
3.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020321 VERIFIED: YES
Provenance & Taxonomy
Crinia deserticola [Animal]
Signiferin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
3-10
Bio-Activity Profile
Smooth muscle contraction Splenocyte proliferation
PaperV.M. Maselli et al. / Rapid Communications in Mass Spectrometry 20 (2006) 797-803. Host-defence skin peptides of the Australian Streambank Froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry Evidence URLhttps://www.uniprot.org/uniprotkb/P86123/entry
RECORD: Rec_0050370 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
326986
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PMID15317042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15317042/
RECORD: Rec_0058843 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
signiferin
326986
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-10
Bio-Activity Profile
Vasoactive Vasodilator Growth regulation Development regulation Myotropic Receptor modulation
CCK-BR
Mammalian: 1 hour; Yeast: 2 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for signiferin 1 (Crinia signifera): PMID 15317042 PMID15317042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15317042/
RECORD: Rec_0098399 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 60.0%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0115279 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
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