Peptide Database

Peptide NameAdrenomedullin 2

Function Ontology

Cardiovascular

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC226H362N74O65S2

DescriptionStandard

        PHAQLLRVGCVLGTCQVQNLSHRLWQLVRPSGRRDSAPVDPSSPHSY
    

Molecular Weight5219.88 Da

Isoelectric Point (pI)9.71

Net Charge (pH 7.0)3.20

Net Charge (pH 7.4) 2.96

Charge Density (pH 7.0) 0.0681

GRAVY Index-0.45

Hydrophobic Moment 0.74

Boman Index-0.09

Instability Index57.52

Aliphatic Index 84.89

Aromaticity 0.0426

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2215.99

LogP -26.39

H-bond Donors 80.0

H-bond Acceptors 73.0

Rotatable Bonds 163.0

Heavy Atoms 367.0

Ring Count 11.0

Amide Bonds 51.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0093673 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

Tax ID10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide10-15

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0165054 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyAdrenomedullin

Tax ID10116

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide10-15

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Receptor modulation Feeding regulator

Half-LifeMammalian: >20 hour; Yeast: >20 hour; E. coli: ?

RECORD: Rec_0209516 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-Cell Communication

RECORD: Rec_0328781 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyAdrenomedullin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Hormone Vasoregulatory peptide