Peptide Database

Peptide NameNaD1 (1-34)-NaD2 (35-40)-NaD1 (41-47)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC225H371N73O64S8

DescriptionStandard

        RECKTESNTFPGICITKPPCRKACISEKFTDGHCRGFRRRCLCTKPC
    

Molecular Weight5379.32 Da

Isoelectric Point (pI)9.27

Net Charge (pH 7.0)6.77

Net Charge (pH 7.4) 6.39

Charge Density (pH 7.0) 0.1441

GRAVY Index-0.69

Hydrophobic Moment 0.72

Boman Index-0.30

Instability Index75.17

Aliphatic Index 35.32

Aromaticity 0.0638

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2230.84

LogP -26.99

H-bond Donors 88.0

H-bond Acceptors 80.0

Rotatable Bonds 177.0

Heavy Atoms 370.0

Ring Count 8.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0035934 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetHuman histiocytic lymphoma U-937 10-20% Killing

Activity10 μM

RECORD: Rec_0299122 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

RECORD: Rec_0360134 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

RECORD: Rec_0377957 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetFusarium oxysporum f.sp. vasinfectum

Activity2.7

MethodIC50

RECORD: Rec_0400960 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetU-937

Activity13.7±8.1 %

MethodCytotoxicity