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MYP_105983
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Basic Information
Anoplin[2-6]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXLKRXKTLL
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0153115 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
64 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0216611 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. typhimurium LT2
64 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0253615 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli O157:H7
32 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0288144 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Hemolytic
Sheep RBC
64 μM
Hemolysis
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0298359 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO1
64 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
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