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MYP_105983
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Basic Information
Anoplin[2-6]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXLKRXKTLL
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054083 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli WR 3551/98 ESBL+
64 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0099789 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis 168
8 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0105397 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli 1841/06 ESBL+
32 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0115591 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC BAA1720 methicillin-resistant Staphylococcus aureus
8 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0139532 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O2-O6: stapled at 2,6; (S)-2-(4?-pentenyl)-alanine, O2-O6: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli K12 MG1655
64 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
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