Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length191 amino acids

Chemical FormulaC961H1524N264O258S10

DescriptionStandard

        MAHEPMLLLAVTEFVTNSAAFTYFTAGALRRNISSDMLPRRFPLQLRTKSMEVFSPQLQERYPDQPMELHLWARQQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLVPDPELAWTPLPALCRAQGLPVPQVKRLETLLKFGLWLFGVPRANSKCCPCPVP
    

Molecular Weight21224.64 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)5.82

Net Charge (pH 7.4) 5.30

Charge Density (pH 7.0) 0.0305

GRAVY Index0.03

Hydrophobic Moment 0.57

Boman Index0.09

Instability Index55.45

Aliphatic Index 93.98

Aromaticity 0.0785

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8203.52

LogP -96.26

H-bond Donors 283.0

H-bond Acceptors 278.0

Rotatable Bonds 666.0

Heavy Atoms 1493.0

Ring Count 43.0

Amide Bonds 205.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0301513 VERIFIED: NO

Provenance & Taxonomy

OrganismPloceus nigricollis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria