Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length475 amino acids

Chemical FormulaC2326H3661N585O705S14

DescriptionStandard

        MRQFLAVLLLVTSSSGESPALQVALSSKALQYGASAGPQWVTEKLKNISLPDISGEMFILVDTLYYTLTGITIENLEIPEPSVEFYPESTGLKTSVSGLGVALRGGWMTTYGLIHDGGSFQIAVVDVAVTSVVRLGREVDGHPLVTSVSCEAHVGDVHMNFEGGASWIFQPFVHQLAGRLRGEMEEKICPSLEDSIAKFDYHLLAINISIDVNKDLTLDLSLTDEPVVDVSSLNVGLKGAIYSSKTHAEPPFEPQDFTMAEQPDFMLSLGVSEYTLNSALYAYYSAGLLQVFINESMVPSYSPVHLNTSSVGAFIPQLPEMYPDLLMDLQVYAREVPLVSFQPGLLQLDLQGAVKAFAVQRNGTQIPLFTLNTDSKFSGKVWISGGRVKGSVELNNLTLTLEATEIGQFETGKLEKFAGIGARLAMSKLNRLLGEGVDLPRLKQAELVNTTLEVEKGFVTILTDAQISLPDGMFN
    

Molecular Weight51549.35 Da

Isoelectric Point (pI)4.67

Net Charge (pH 7.0)-23.74

Net Charge (pH 7.4) -24.51

Charge Density (pH 7.0) -0.0500

GRAVY Index0.14

Hydrophobic Moment 0.74

Boman Index0.17

Instability Index35.53

Aliphatic Index 102.78

Aromaticity 0.0821

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 42985.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0373368 VERIFIED: NO

Provenance & Taxonomy

OrganismTetraodon nigroviridis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence