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MYP_105887
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Basic Information
MBD-4 (11-40)(P9)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C144H227N47O35S5
Standard
Sequence
NGAICWGPCPTAFRQIGNCGHFKVRCCKIR
Physicochemical Analysis
3336.96 Da
9.41
4.80
4.47
0.1599
-0.07
0.60
-0.01
-1.33
55.33
0.1000
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1321.35
-13.90
51.0
46.0
105.0
231.0
7.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0120387 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Human Influenza A Virus H5N1
2.4 μg/mL
IC50
PMID26911565;32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26911565/
RECORD: Rec_0124019 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Human Influenza A Virus H7N9 | MDCK cells
3.3 μg/mL
IC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperA broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. | Zhao H, To KKW, Sze KH, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY. | Nat Commun. 2020 Aug 25;11(1):4252. | DOI:10.1038/s41467-020-17986-9 | PMID:32843628 PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0124151 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin-derived peptide
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
8.8 μg/mL
IC50
PaperA broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2 PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0126748 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Replication inhibition
SARS-CoV-2 | E6 cells
2.4 μg/mL
IC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperA broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. | Zhao H, To KKW, Sze KH, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY. | Nat Commun. 2020 Aug 25;11(1):4252. | DOI:10.1038/s41467-020-17986-9 | PMID:32843628 PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0157337 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
H3N2
PMID29907765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29907765/
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