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MYP_105855
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Basic Information
Malanin chain A (Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
10 amino acids
C54H81N11O18
Standard
Sequence
DYPKLTFTTS
Physicochemical Analysis
1172.28 Da
5.83
-0.24
-0.45
-0.0241
-0.66
0.18
-0.01
25.19
39.00
0.2000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
480.90
-4.76
17.0
18.0
34.0
83.0
3.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020045 VERIFIED: YES
Provenance & Taxonomy
Malania oleifera [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Anticancer Cytotoxic
Cancer cell lines: HeLa
0.00015±0.00008 μM
IC50
PaperPubMed PMID: 19341757 PMID19341757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19341757/
RECORD: Rec_0083702 VERIFIED: YES
Provenance & Taxonomy
Malania oleifera [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7
0.0112±0.00002 μM
IC50
PaperPubMed PMID: 19341757 PMID19341757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19341757/
RECORD: Rec_0157269 VERIFIED: YES
Provenance & Taxonomy
Malania oleifera [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Anticancer Cytotoxic
Non-cancer cell lines: Vero (IC50=2.79±0.05 nM) and Madin-Darby canine kidney cells
0.00392±0.00001 μM
IC50
PaperPubMed PMID: 19341757 PMID19341757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19341757/
RECORD: Rec_0159370 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP00301
RECORD: Rec_0218884 VERIFIED: YES
Provenance & Taxonomy
Malania oleifera [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Anticancer Cytotoxic
PC-12
0.00771±0.00024 μM
IC50
PaperPubMed PMID: 19341757 PMID19341757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19341757/
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