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MYP_105622
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Basic Information
E6apn1
Antimicrobial
Antiviral
Antiviral ▸ Anti-HPV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
23 amino acids
C106H168N30O33
Standard
Sequence
ALQELLGQWLKDGGPSSGRPPPS
Physicochemical Analysis
2390.65 Da
6.11
-0.20
-0.39
-0.0087
-0.73
0.54
0.01
89.40
72.17
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
993.54
-11.22
32.0
33.0
73.0
169.0
6.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0100581 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HPV Entry inhibition
Human papillomavirus(HPV)
36.8±3.2 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 Jun 15;43(23):7421-31. | DOI:10.1021/bi049552a | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0134499 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0195714 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 56.5%, E 0.0%, T 21.7%, C 21.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0264647 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human papillomavirus(HPV):inhibition of E6-E6ap interaction
36.8±3.2 μM
IC50
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0367943 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Host-derived peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human papillomavirus (E6 protein)
36.8 μM
CD spectroscopy
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/