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MYP_105496
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Basic Information
RJ7
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C115H201N35O22
Standard
Sequence
AKKAWKKAKKAAKKAKKWAKK
Physicochemical Analysis
2426.05 Da
11.04
11.78
11.58
0.5611
-1.71
0.72
-0.57
2.37
33.33
0.0952
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
989.14
-5.77
36.0
34.0
93.0
172.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0279919 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
herpes simplex virus 1 (HSV-1) | MRC-5 cells
40.8 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperA wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus. | Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. | Antiviral Res. 2004 Nov;64(2):119-26. | DOI:10.1016/j.antiviral.2004.08.003 | PMID:15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0325155 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Herpes simplex virus 1 (Replication); MRC-5
40.8 μM
Plaque assay
PaperA wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus. | Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. | Antiviral Res. 2004 | PMID:15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0351976 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0353452 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
herpes simplex virus 2(HSV-2):inhibition of HSV-2 infection in MRC-5 cells
44.9 μM
IC50
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
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