Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length56 amino acids

Chemical FormulaC257H429N71O85S5

DescriptionStandard

        MKSTNNQSIAEIAAVNALQEVSMEELDQIIGAGNGVVLTLTHECNLATWTKKLKCC
    

Molecular Weight6033.91 Da

Isoelectric Point (pI)5.05

Net Charge (pH 7.0)-2.43

Net Charge (pH 7.4) -2.76

Charge Density (pH 7.0) -0.0434

GRAVY Index0.07

Hydrophobic Moment 0.43

Boman Index0.11

Instability Index25.89

Aliphatic Index 101.07

Aromaticity 0.0179

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2542.73

LogP -28.48

H-bond Donors 88.0

H-bond Acceptors 89.0

Rotatable Bonds 208.0

Heavy Atoms 418.0

Ring Count 3.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0153146 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus thermophilus [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence

RECORD: Rec_0226448 VERIFIED: NO