Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2588H4037N643O738S19

DescriptionStandard

        MMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGMEMIEQMVKKRNIPDLKGSESLEFLKIDYVNYNFKNIKINAFSLPNTSLAFVPGVGIRALINHGTANISTDWEIKSPLFQDTGGADLFLSGVYFTGIVVLAWNDFGHPILKLQNCCAQVSHSDVSFSGELSVLYNSFAEPMEKRILKNLNKMLCPIITSEVEALNANFSMLKALRKIDNYTLLDYSLISSPEITENYVDLNLKGVFYPLENLTDTPFSSVPFVLPEHSDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTKEIFNHLIRNSQGLGSMLSRIAELYILSQPFMVKVLATEPPVVNLLPGNFTLDIPASFVIFTQSKNSTAKTIVSMDFVASTNVALAILGQRLICSLSLKSFYLSLPESSRSNTEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPQNISLVNSDIEVLEGFLLISTDLKYKTSLKQQPSFHGWEALNLISGQWRGKPAP
    

Molecular Weight56575.84 Da

Isoelectric Point (pI)6.41

Net Charge (pH 7.0)-1.91

Net Charge (pH 7.4) -2.68

Charge Density (pH 7.0) -0.0038

GRAVY Index0.16

Hydrophobic Moment 0.87

Boman Index0.17

Instability Index39.45

Aliphatic Index 103.07

Aromaticity 0.1083

Extinction Coeff. Reduced 59820.00

Extinction Coeff. Oxidized 60195.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221116 VERIFIED: NO

Provenance & Taxonomy

OrganismBalaenoptera acutorostrata scammoni [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence