Peptide Database

Peptide NameAscaphin-8-1

Function Ontology

Anticancer

Anticancer ▸ Antitumor

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC97H165N23O23

DescriptionStandard

        GFKSLLKSAAKALVKTVLF
    

Molecular Weight2021.49 Da

Isoelectric Point (pI)10.48

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.1977

GRAVY Index0.86

Hydrophobic Moment 0.64

Boman Index0.25

Instability Index-4.42

Aliphatic Index 128.42

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 751.89

LogP -4.32

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 70.0

Heavy Atoms 143.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0061683 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Hemolytic

Targetrabbit RBCs

Activity79.89 μM

MethodHC50

RECORD: Rec_0181033 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetHEK293T

Activity33.91 μM

MethodIC50

RECORD: Rec_0203603 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetA549

Activity4.10 μM

MethodIC50

RECORD: Rec_0330750 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetC4-2B

Activity11.09 μM

MethodIC50