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MYP_105246
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
41 amino acids
C222H388N58O59
Standard
Sequence
IKKEIEAIKKEQEAIKKKIEAIEKLLQLTVWGIKQLQARIL
Physicochemical Analysis
4813.81 Da
9.70
3.77
3.54
0.0919
-0.25
0.62
-0.07
65.34
140.49
0.0244
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1955.58
-9.46
66.0
63.0
181.0
339.0
2.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0086242 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HIV gp41 N-peptide fusion inhibitor
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibitor
HIV-1 BaL
0.0032 μM
IC50
PaperCovalently stabilized chimeric coiled-coil HIV gp41 N-peptides with improved antiviral activity Evidence URLhttps://patents.google.com/patent/US7811577B2/en PatentUS 7811577 B2
RECORD: Rec_0113333 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HIV gp41 N-peptide fusion inhibitor
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibitor
HIV-1 HXB2
0.0017 μM
IC50
PaperCovalently stabilized chimeric coiled-coil HIV gp41 N-peptides with improved antiviral activity Evidence URLhttps://patents.google.com/patent/US7811577B2/en PatentUS 7811577 B2
RECORD: Rec_0234000 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID11572974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11572974/
RECORD: Rec_0234216 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
PaperPatent US 7811577 B2 Evidence URLhttps://patents.google.com/patent/US7811577B2/en PatentUS 7811577 B2
RECORD: Rec_0248515 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | 293T cells; HOS-CD4/fusion cells
0.022±0.011 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperDesign of potent inhibitors of HIV-1 entry from the gp41 N-peptide region. | Eckert DM, Kim PS. | Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11187-92. | DOI:10.1073/pnas.201392898 | PMID:11572974 PMID11572974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11572974/