‹ ›
MYP_105207
← PREVIOUS NEXT → BACK
Basic Information
NYBSP-4
Antiviral
Standard
30 amino acids
C161H233N39O53
Standard
Sequence
TIEEQAKTFLDKFNHEAEDLFYQSSLASWN
Physicochemical Analysis
3562.80 Da
4.35
-4.50
-4.76
-0.1501
-0.74
0.54
-0.03
85.35
62.00
0.1667
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1521.27
-14.25
51.0
50.0
118.0
253.0
7.0
33.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0317575 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ (position: 13,24 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ (position: 6) indicates 2-(7'-octenyl) alanine in the R configuration. Ⓩ(6) and Ⓧ(13), Ⓧ(24) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
A549/ACE2 cells (SARS-CoV-2 infection)
2.8±0.08 μM
IC50
human plasma: >289 min
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0321284 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
27.7 μM
IC50
PaperStapled peptides based on human angiotensin-converting enzyme 2 (ACE2) potently inhibit SARS-CoV-2 infection in vitro PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0358904 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ(position: 13 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ(position: 6 and 21) indicate 2-(7'-octenyl) alanine in the R configuration. Ⓩ(6) and Ⓧ(13), Ⓩ(21) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
A549/ACE2 cells (VSV-G infection)
>26.8 μM
IC50
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0359407 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ (position: 9,13 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ (position: 21) indicates 2-(7'-octenyl) alanine in the R configuration. Ⓧ(9) and Ⓧ(13), Ⓩ(21) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
HT1080/ACE2 cells (SARS-CoV-2 infection)
12.9±0.35 μM
IC50
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0378184 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ(position: 13 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ(position: 6 and 21) indicate 2-(7'-octenyl) alanine in the R configuration. Ⓩ(6) and Ⓧ(13), Ⓩ(21) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
A549/ACE2 cells
>26.8 μM
CC50
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
FIRST PREV 1 ... 3 4 5 6 NEXT LAST
Showing 5 records on this page · Page 5 of 6