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MYP_105207
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Basic Information
NYBSP-4
Antiviral
Standard
30 amino acids
C161H233N39O53
Standard
Sequence
TIEEQAKTFLDKFNHEAEDLFYQSSLASWN
Physicochemical Analysis
3562.80 Da
4.35
-4.50
-4.76
-0.1501
-0.74
0.54
-0.03
85.35
62.00
0.1667
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1521.27
-14.25
51.0
50.0
118.0
253.0
7.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074918 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ(position: 13 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ(position: 6 and 21) indicate 2-(7'-octenyl) alanine in the R configuration. Ⓩ(6) and Ⓧ(13), Ⓩ(21) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
Vero E6 cells (SARS-CoV-2 CPE)
33.5 μM
IC100
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0081542 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ (position: 9,13,24 and 28) in sequence indicate S-2-(4'-pentenyl) alanine. Ⓧ(9) and Ⓧ(13), Ⓧ(24) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
HT1080/ACE2 cells (VSV-G infection)
>27.5 μM
IC50
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0108667 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ (position: 9,13 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ (position: 21) indicates 2-(7'-octenyl) alanine in the R configuration. Ⓧ(9) and Ⓧ(13), Ⓩ(21) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
A549/ACE2 cells
>27.6 μM
CC50
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0112501 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ (position: 13,24 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ (position: 6) indicates 2-(7'-octenyl) alanine in the R configuration. Ⓩ(6) and Ⓧ(13), Ⓧ(24) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
A549/ACE2 cells (VSV-G infection)
>26.6 μM
IC50
human plasma: >289 min
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
RECORD: Rec_0113399 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acylation
Amidation
The Ⓧ (position: 9,13 and 28) in sequence indicate S-2-(4'-pentenyl) alanine.The Ⓩ (position: 21) indicates 2-(7'-octenyl) alanine in the R configuration. Ⓧ(9) and Ⓧ(13), Ⓩ(21) and Ⓧ(28) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antiviral
A549/ACE2 cells (VSV-G infection)
>27.6 μM
IC50
PaperCurreli F, Victor SMB, Ahmed S, Drelich A, Tong X, Tseng CK, Hillyer CD, Debnath AK. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. mBio. 2020 Dec 11;11(6):e02451-20. PMID33310780 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33310780/
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