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MYP_105169
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
17 amino acids
C60H105N17O26S5
Standard
Sequence
IASASCTTCICTCSCSS
Physicochemical Analysis
1640.90 Da
5.49
-0.29
-0.57
-0.0170
1.12
0.14
0.26
97.45
57.65
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
690.76
-13.96
31.0
31.0
50.0
108.0
0.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0298898 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Thiopeptide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Thiazoline residue
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Antimalarial
Plasmodium falciparum Dd2
1.3±0.10 μM
IC50; PLDH assay
PaperThiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast PMID21245445 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21245445/
RECORD: Rec_0300560 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Ring C thiazole, R - CH2Ph
Bio-Activity Profile
Antimicrobial Antiparasitic Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0311859 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Thiopeptide
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Ring C thiazoline, R - (CH2)8H
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum
4.3±1.2 μM
IC50; PLDH assay
PMID20358566 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20358566/
RECORD: Rec_0313190 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Thiopeptide
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Ring C thiazoline, R - CH2CHNAcCO2Me
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum
PLDH assay
PMID20358566 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20358566/
RECORD: Rec_0316348 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Thiopeptide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Thiazole
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Antimalarial
Plasmodium falciparum Dd2
0.16 μM
IC50; PLDH assay
PaperThiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast PMID21245445 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21245445/
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