‹ ›
MYP_105169
← PREVIOUS NEXT → BACK
Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
17 amino acids
C60H105N17O26S5
Standard
Sequence
IASASCTTCICTCSCSS
Physicochemical Analysis
1640.90 Da
5.49
-0.29
-0.57
-0.0170
1.12
0.14
0.26
97.45
57.65
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
690.76
-13.96
31.0
31.0
50.0
108.0
0.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0139042 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Thiopeptide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Thiazoline residue
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Antimalarial
Plasmodium falciparum 3D7
3.5±0.44 μM
IC50; PLDH assay
PaperThiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast PMID21245445 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21245445/
RECORD: Rec_0159241 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Thiopeptide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Thiazoline residue
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Antimalarial
Plasmodium falciparum Dd2
0.77±0.097 μM
IC50; PLDH assay
PaperThiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast PMID21245445 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21245445/
RECORD: Rec_0160563 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Thiopeptide
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Ring C thiazoline
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum
PLDH assay
PMID20358566 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20358566/
RECORD: Rec_0168722 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Ring C thiazole
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0169872 VERIFIED: YES
Provenance & Taxonomy
Streptomyces azureus [Bacterium]
thiocillin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
3-Ser: 2,3-didehydroalanine (Ser); 8-Thr: (Z)-2,3-didehydrobutyrine; 10-Ile: (3S,4R)-3,4-dihydroxyisoleucine; 16-Ser: 2,3-didehydroalanine (Ser); 17-Ser: 2,3-didehydroalanine (Ser)
Bio-Activity Profile
Antimicrobial thiocillin family Antibacterial Host defense
PaperPDB 2JQ7 structural record; NMR; chain C; residues 1-17
FIRST PREV 1 2 3 4 5 6 ... 9 NEXT LAST
Showing 5 records on this page · Page 4 of 9