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MYP_105169
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
17 amino acids
C60H105N17O26S5
Standard
Sequence
IASASCTTCICTCSCSS
Physicochemical Analysis
1640.90 Da
5.49
-0.29
-0.57
-0.0170
1.12
0.14
0.26
97.45
57.65
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
690.76
-13.96
31.0
31.0
50.0
108.0
0.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019264 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Ring C thiazole, R - (CH2)8H
Bio-Activity Profile
Antiparasitic Antiplasmodial Antimicrobial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0050513 VERIFIED: YES
Provenance & Taxonomy
Streptomyces laurentii ATCC 31255 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-Gram-positive Antimicrobial Antibacterial
methicillin-resistant Staphylococcus aureus ATCC 10537; vancomycin-resistant Enterococcus faecium ATCC 12952; Bacillus sp. ATCC 27859
0.012; 0.012; 0.025 μg/mL
MIC
PMID26630475 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26630475/
RECORD: Rec_0055625 VERIFIED: YES
Provenance & Taxonomy
Streptomyces laurentii ATCC 31255 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-Gram-positive Antimicrobial Antibacterial
Bacillus sp. ATCC 27859
0.025 μg/mL
MIC
PMID26630475 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26630475/
RECORD: Rec_0062015 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Thiopeptide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Thiazoline residue
Bio-Activity Profile
Antibiotic Antiparasitic Antimalarial Antimicrobial
Plasmodium falciparum Dd2
1.7±0.27 μM
IC50; PLDH assay
PaperThiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast PMID21245445 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21245445/
RECORD: Rec_0080900 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Thiopeptide
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Ring C thiazole
Bio-Activity Profile
Antiparasitic Antimalarial Antimicrobial
Plasmodium falciparum
3.1±0.3 μM
IC50; PLDH assay
PMID20358566 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20358566/
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