Peptide Database

Peptide NameSLAY-screened peptide P2142

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC91H146N22O31S

DescriptionStandard

        PTTDSLPAGCNFTPLTSQLI
    

Molecular Weight2076.33 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.05

Net Charge (pH 7.4) -1.12

Charge Density (pH 7.0) -0.0525

GRAVY Index0.14

Hydrophobic Moment 0.32

Boman Index0.22

Instability Index40.51

Aliphatic Index 83.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 829.51

LogP -10.82

H-bond Donors 29.0

H-bond Acceptors 31.0

Rotatable Bonds 61.0

Heavy Atoms 145.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0185036 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/