Peptide Database

Peptide NameSLAY-screened peptide P2918

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H159N29O30S

DescriptionStandard

        PISKMAINATWIGHDDRWTY
    

Molecular Weight2375.66 Da

Isoelectric Point (pI)7.17

Net Charge (pH 7.0)0.05

Net Charge (pH 7.4) -0.07

Charge Density (pH 7.0) 0.0023

GRAVY Index-0.52

Hydrophobic Moment 0.27

Boman Index0.06

Instability Index41.81

Aliphatic Index 68.50

Aromaticity 0.1500

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 949.02

LogP -7.07

H-bond Donors 35.0

H-bond Acceptors 32.0

Rotatable Bonds 73.0

Heavy Atoms 168.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425970 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/