Peptide Database

Peptide NameCaerin-1.5 (Frogs, amphibians, animals)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC123H206N32O30

DescriptionStandard

        GLLSVLGSVVKHVIPHVVPVIAEHL
    

Molecular Weight2613.15 Da

Isoelectric Point (pI)7.02

Net Charge (pH 7.0)0.02

Net Charge (pH 7.4) -0.33

Charge Density (pH 7.0) 0.0009

GRAVY Index1.31

Hydrophobic Moment 0.50

Boman Index0.50

Instability Index19.69

Aliphatic Index 178.80

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 933.96

LogP -3.93

H-bond Donors 31.0

H-bond Acceptors 33.0

Rotatable Bonds 81.0

Heavy Atoms 185.0

Ring Count 5.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423741 VERIFIED: YES

Provenance & Taxonomy

OrganismPelodryas caerulea [Animal]

FamilyCaerin

Tax ID30344

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV Release inhibition

TargetHIV | T cells

Activity3 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of HIV infection by caerin 1 antimicrobial peptides. | VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA. | Peptides. 2015 Sep;71:296-303. | DOI:10.1016/j.peptides.2015.05.004 | PMID:26026377 PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/

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