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MYP_105117
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Basic Information
Caerin-1.5 (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C123H206N32O30
Standard
Sequence
GLLSVLGSVVKHVIPHVVPVIAEHL
Physicochemical Analysis
2613.15 Da
7.02
0.02
-0.33
0.0009
1.31
0.50
0.50
19.69
178.80
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
933.96
-3.93
31.0
33.0
81.0
185.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0260291 VERIFIED: YES
Provenance & Taxonomy
Litoria caerulea [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antimicrobial Antibacterial
Micrococcus luteus
12 μg/mL
MIC
PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0280213 VERIFIED: YES
Provenance & Taxonomy
Litoria caerula [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Antibacterial
B. cereusV, Listeria innocua and Streptococcus uberis
50 μg/mL
MIC
PaperPeptides from Australian frogs. The structures of the caerins from Litoria caerula.
RECORD: Rec_0321341 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial Antimicrobial
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0323400 VERIFIED: YES
Provenance & Taxonomy
Litoria caerulea [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antimicrobial Antibacterial
Leuconostoc lactis
3 μg/mL
MIC
PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0327092 VERIFIED: YES
Provenance & Taxonomy
Litoria caerulea [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antimicrobial Antibacterial Antiviral
Streptococcus uberis
50 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID26026377;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
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