Peptide Database

Peptide Nameadrenomedullin-(22-52) (human)

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC159H251N45O49

DescriptionStandard

        TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY
    

Molecular Weight3576.97 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)1.48

Net Charge (pH 7.4) 1.23

Charge Density (pH 7.0) 0.0478

GRAVY Index-1.06

Hydrophobic Moment 0.64

Boman Index-0.21

Instability Index29.15

Aliphatic Index 62.90

Aromaticity 0.0968

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1562.13

LogP -16.93

H-bond Donors 52.0

H-bond Acceptors 52.0

Rotatable Bonds 119.0

Heavy Atoms 253.0

Ring Count 6.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0285395 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Receptor antagonist Vasoactive Signaling peptide

TargetAM1 receptor (Human); AM2 receptor (Human)

Activity15.8-100 nM

MethodKi