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MYP_105040
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Basic Information
Neutrophil defensin 1 (Defensin, alpha 1; HNP-1, HP-1; Human, mammals, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Wound healing/Regeneration ▸ Wound healing
Standard
30 amino acids
C150H228N44O38S6
Standard
Sequence
ACYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
3448.08 Da
8.68
2.74
2.45
0.0912
0.30
0.49
0.07
55.71
65.33
0.1667
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1323.13
-10.92
55.0
47.0
105.0
238.0
7.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294202 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-30; 4-19; 9-29
Bio-Activity Profile
Host-defense peptide Antiparasitic Anti-Trypanosoma cruzi Antimicrobial
Trypanosoma cruzi Y (amastigote)
5-10 μM
Microscopy
PMID17635867 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17635867/
RECORD: Rec_0295827 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0296776 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
-
2-30; 4-19; 9-29
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Anti-SARS-CoV-2 Antimicrobial Antibacterial Antifungal Antiviral
SARS-CoV-2 variant P.1; HeLa-hACE2 cells
67 %
infection inhibition at 50 μg/mL
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 19253295 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. | PubMed PMID: 15118082 PMID34206990;19253295;15616305;15118082 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0297763 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-30; 4-19; 9-29
Bio-Activity Profile
Antimycobacterial Antimicrobial Antibacterial
Mycobacterium avium- mycobacterium intracellularae strain 475049
MIC
PMID1398982 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1398982/
RECORD: Rec_0302141 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
-
2-30; 4-19; 9-29
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Anti-SARS-CoV-2 Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 25923
4.2±1.0 μg/mL
vLD50
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 19253295 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. | PubMed PMID: 15118082 PMID34206990;19253295;15616305;15118082 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
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