‹ ›
MYP_105040
← PREVIOUS NEXT → BACK
Basic Information
Neutrophil defensin 1 (Defensin, alpha 1; HNP-1, HP-1; Human, mammals, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Virucidal activity
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Wound healing
Standard
30 amino acids
C150H228N44O38S6
Standard
Sequence
ACYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
3448.08 Da
8.68
2.74
2.45
0.0912
0.30
0.49
0.07
55.71
65.33
0.1667
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1323.13
-10.92
55.0
47.0
105.0
238.0
7.0
30.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0102547 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization(Cys2 and Cys30).
2-30, 4-19, 9-29
Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29.; Cyclization(Cys2 and Cys30).
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 variant P.1 | HeLa-hACE2 cells
50 μg/mL
% inhibition
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. | Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL. | Viruses. 2021 Jun 26;13(7):1246. | DOI:10.3390/v13071246 | PMID:34206990 PMID34206990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0130313 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-30, 4-19, 9-29
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
PaperScalable recombinant production of bioactive human neutrophil peptide-1 in Komagataella phaffii PMID41350511 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41350511/
RECORD: Rec_0134168 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
Disulfide linkage reported
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium avium- mycobacterium intracellularae strain 25291
MIC
PMID1398982 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1398982/
RECORD: Rec_0138938 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
Disulfide linkage reported
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium tuberculosis Ra 11170G
MIC
PMID8641802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8641802/
RECORD: Rec_0139248 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30; 4-19; 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
Staphylococcus aureus (Inhibition zone=1 mm in PH5.5, Inhibition zone=7 mm incompletely inhibit and Inhibition zone=2 mm completely inhibit in PH7.5 at 10 μg/well)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 19253295 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. | PubMed PMID: 15118082 PMID34206990;19253295;15616305;15118082 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
FIRST PREV 1 2 3 4 5 6 ... 14 NEXT LAST
Showing 5 records on this page · Page 4 of 14