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MYP_105040
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Basic Information
Neutrophil defensin 1 (Defensin, alpha 1; HNP-1, HP-1; Human, mammals, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Wound healing/Regeneration ▸ Wound healing
Standard
30 amino acids
C150H228N44O38S6
Standard
Sequence
ACYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
3448.08 Da
8.68
2.74
2.45
0.0912
0.30
0.49
0.07
55.71
65.33
0.1667
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1323.13
-10.92
55.0
47.0
105.0
238.0
7.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0089232 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606;0
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
2-30; 4-19; 9-29
Bio-Activity Profile
Virucidal Antiviral
Herpes simplex virus 1 (Virucidal); Vero
Plaque assay
PaperDirect inactivation of viruses by human granulocyte defensins. | Daher KA, Selsted ME, Lehrer RI. | J Virol. 1986 | PMID:3023659 PMID3023659 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3023659/
RECORD: Rec_0090208 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Terminally blocked antiviral peptide
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Anti-HIV Antiviral
HIV
PaperTerminally blocked antiviral peptides Evidence URLhttps://patents.google.com/patent/US5447915A/en PatentUS 5447915 A
RECORD: Rec_0091850 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
2-30; 4-19; 9-29
Paclitaxel conjugation
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0100106 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
-
2-30; 4-19; 9-29
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Anti-SARS-CoV-2 Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 8739
3.6±0.3 μg/mL
vLD50
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 19253295 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. | PubMed PMID: 15118082 PMID34206990;19253295;15616305;15118082 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0102547 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
-
2-30; 4-19; 9-29
-
Bio-Activity Profile
Anti-SARS-CoV-2 Entry inhibition Antiviral
SARS-CoV-2 variant P.1; HeLa-hACE2 cells
50 μg/mL
% inhibition
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. | Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL. | Viruses. 2021 Jun 26;13(7):1246. | DOI:10.3390/v13071246 | PMID:34206990 PMID34206990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
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