Peptide Database

Peptide NameNeutrophil defensin 1 (Defensin, alpha 1; HNP-1, HP-1; Human, mammals, animals)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Virucidal activity

Immunology ▸ Immune cell migration ▸ Chemotactic peptide

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Wound healing/Regeneration ▸ Wound healing

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC150H228N44O38S6

DescriptionStandard

        ACYCRIPACIAGERRYGTCIYQGRLWAFCC
    

Molecular Weight3448.08 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.45

Charge Density (pH 7.0) 0.0912

GRAVY Index0.30

Hydrophobic Moment 0.49

Boman Index0.07

Instability Index55.71

Aliphatic Index 65.33

Aromaticity 0.1667

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1323.13

LogP -10.92

H-bond Donors 55.0

H-bond Acceptors 47.0

Rotatable Bonds 105.0

Heavy Atoms 238.0

Ring Count 7.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0424180 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide2-30; 4-19; 9-29

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2

TargetNOTE: vLD50

PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 19253295 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. | PubMed PMID: 15118082 PMID34206990;19253295;15616305;15118082 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/

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