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MYP_105008
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Basic Information
Maculatin 1.3
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
21 amino acids
C98H159N25O24
Standard
Sequence
GLLGLLGSVVSHVVPAIVGHF
Physicochemical Analysis
2071.46 Da
6.92
-0.07
-0.37
-0.0031
1.62
0.40
0.65
14.84
166.67
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
734.35
-4.18
25.0
26.0
63.0
147.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0324342 VERIFIED: YES
Provenance & Taxonomy
Litoria eucnemis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-HIV-1 Entry inhibition Antiviral
HIV-1 IIIB; CEM-SS cells
4 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0349132 VERIFIED: NO
Provenance & Taxonomy
Litoria eucnemis [Animal]
Maculatin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0354590 VERIFIED: NO
Provenance & Taxonomy
Litoria chloris [Animal]
Blue-thighed frog,Litoria chloris, Australia
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
-
PMID22771617;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22771617/
RECORD: Rec_0362764 VERIFIED: YES
Provenance & Taxonomy
Litoria eucnemis [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C-terminal NH2
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Antibacterial
Staphylococcus aureus USA300 MRSA
6.2 μM
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. PMID15203252
RECORD: Rec_0370854 VERIFIED: YES
Provenance & Taxonomy
Litoria eucnemis [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C-terminal NH2
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Antibacterial
Escherichia coli
>100 μM
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. PMID15203252
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