Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2602H4009N649O745S17

DescriptionStandard

        MRIKKIPVLWGCFLLWNLYISSSHAVYPGIKARITQQALDYGVEVGMKVLEQMMKEKTIPDIIGSESLEFLKIDYVNYNFSNIKVNALSFPNTSLAFVPGVGLKVLTNHGTANISNHWEVKSPLFYDTGESDLYLSGIYFTGIIVLTRNEVGHPALKLTDCYAQVSHAHVSFAGGLSVLYNSFAEPMEKPILRNLNEMLCPMITNEVEAFNVNLSALEVLIKIDNYTLLDCSLVSSPEISEHYLDLNLKGVFYPLENLADPNFSPVPFVLPDRRDSMLYIGISEYFFRSASFAHFVAGAFGATLSTKEISHYFVQNSQGFGNFLSRIAEIYILSQPFMLEFMATEPPTVHLEPNNFTLDIPASIIMLTQTENSTVEPIVSMDFVASTSVGLAILGQKLICSLSLNRFRLSLPESNRSDIKVLRFENILSSILHFGVLPLANTRLQQGFPLPNPYNISFINSDIEVLEDFLLISTDLRHETFSKQQPSFHNWGGLNLINGPWRETPTP
    

Molecular Weight56847.67 Da

Isoelectric Point (pI)5.27

Net Charge (pH 7.0)-15.34

Net Charge (pH 7.4) -16.41

Charge Density (pH 7.0) -0.0303

GRAVY Index0.12

Hydrophobic Moment 0.73

Boman Index0.17

Instability Index37.02

Aliphatic Index 102.27

Aromaticity 0.1105

Extinction Coeff. Reduced 54320.00

Extinction Coeff. Oxidized 54570.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0248667 VERIFIED: NO

Provenance & Taxonomy

OrganismDipodomys ordii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria