Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length458 amino acids

Chemical FormulaC2287H3677N593O646S17

DescriptionStandard

        MFLCGWLVMVTLIPVILSVNPGVEVKITDKGIEYGRQLGIAAIQEKLKKIRIPDFSGKQRVSPIGKVQYSLTNIQIVNIGLPIAPIQLVPGSGVKLSINNAFINLRGNWRVKFLRWVKNSGSFEVGMNDLSISESLAVKSDSTGRPEVSTISCAASVGRVRIKFHGGASWLYNLFSKYIEKALKSALQKQICPLVTNAIDDMNPRLKTLNVLANVDKYAEIEYSMVSSPAISSSSIALKLKGQFYNIGQHQEPPFSAPAFSLPPENSNMLYMALSAFTANSAAFVYHKAGVLSIYITDDMIPKRSPIRLTTTTFGTFIPQISKQFPGLMMKLLMKTDKSPVVTFEPDRVTVQVTGTVTAYAIQPNDTLTPLFILNLDTSVSSKVFLSGMKLGVSLTLNKMKLSLQTSYVGQFQVRAAFSTFATGTNIQLGKGYPLPAIRNMELENTKLQILKVRDELF
    

Molecular Weight50361.35 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)19.74

Net Charge (pH 7.4) 19.23

Charge Density (pH 7.0) 0.0431

GRAVY Index0.12

Hydrophobic Moment 0.72

Boman Index0.13

Instability Index37.30

Aliphatic Index 101.51

Aromaticity 0.0852

Extinction Coeff. Reduced 41370.00

Extinction Coeff. Oxidized 41495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0327385 VERIFIED: NO

Provenance & Taxonomy

OrganismTakifugu rubripes (Japanese pufferfish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria