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MYP_104855
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Basic Information
D Magainin-2 [S8A,G13A,G18A]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
23 amino acids
C116H184N30O28S
Standard
Sequence
GIGKFLHAAKKFAKAFVAEIMNS
Physicochemical Analysis
2478.95 Da
10.00
2.85
2.59
0.1237
0.39
0.70
0.22
10.56
85.22
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
936.90
-6.08
32.0
33.0
85.0
175.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208397 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 29213
10 μg/mL
MIC
PMID3410055;26986223;14642822;24102563;26369301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3410055/
RECORD: Rec_0212389 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 27853
25 μg/mL
MIC
PMID3410055;26986223;14642822;24102563;26369301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3410055/
RECORD: Rec_0217590 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
125 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0219319 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis var. niger ATCC 9372
2.21
MIC
PMID3410055;26986223;14642822;24102563;26369301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3410055/
RECORD: Rec_0222856 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial
Daudi
28 μg/mL
IC50
PaperAntibiotic magainins exert cytolytic activity against transformed cell lines through channel formation PMID1708887;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1708887/
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