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MYP_104829
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Basic Information
Dermaseptin-5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C125H212N36O36
Standard
Sequence
GLWSTIKQKGKEAAIAAAKAAGQAALGAL
Physicochemical Analysis
2795.24 Da
10.00
2.76
2.55
0.0951
0.29
0.45
0.21
14.26
101.72
0.0345
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1161.93
-12.06
40.0
39.0
96.0
197.0
2.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0316132 VERIFIED: NO
Provenance & Taxonomy
Pithecopus azureus [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperDermaseptin-H6 (Dermaseptin-H1) (Dermaseptin-like peptide 1, DMS1) (Dermaseptin-like peptide 6, DMS6) Evidence URLhttps://www.uniprot.org/uniprotkb/P84936/entry
RECORD: Rec_0319975 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Hemolytic
Escherichia coli
PMID16844081;18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16844081/
RECORD: Rec_0323878 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperG.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells Evidence URLhttps://www.uniprot.org/uniprotkb/P84600/entry
RECORD: Rec_0325193 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiprotozoal
rabbit red blood cells
PMID8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
RECORD: Rec_0328765 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic
Human erythrocytes
8 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/12379643/ PMID12379643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12379643/
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