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MYP_104829
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Basic Information
Dermaseptin-5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C125H212N36O36
Standard
Sequence
GLWSTIKQKGKEAAIAAAKAAGQAALGAL
Physicochemical Analysis
2795.24 Da
10.00
2.76
2.55
0.0951
0.29
0.45
0.21
14.26
101.72
0.0345
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1161.93
-12.06
40.0
39.0
96.0
197.0
2.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267382 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Schistosoma mansoni worms BH from Belo Horizonte Brazil
200 μg/mL
Microscopy
PMID21404438 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21404438/
RECORD: Rec_0300530 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Staphylococcus aureus
3.2 μM
MIC
PaperDermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.
RECORD: Rec_0301271 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiprotozoal
Staphylococcus aureus
3.2 μM
MIC
PMID12379643;17442605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12379643/
RECORD: Rec_0302391 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
No hemolytic activity
Hemolysis
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ1885
RECORD: Rec_0302450 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Escherichia coli wt MR
6.42 μM
MIC
PMID12379643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12379643/
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