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MYP_104829
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Basic Information
Dermaseptin-5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C125H212N36O36
Standard
Sequence
GLWSTIKQKGKEAAIAAAKAAGQAALGAL
Physicochemical Analysis
2795.24 Da
10.00
2.76
2.55
0.0951
0.29
0.45
0.21
14.26
101.72
0.0345
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1161.93
-12.06
40.0
39.0
96.0
197.0
2.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0186363 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa oreades [Animal]; Phyllomedusa distincta [Animal]; Phyllomedusa hypochondrialis azurea [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic
Trypanosoma cruzi in the
RECORD: Rec_0188828 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic
Human erythrocytes
32 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/12379643/ PMID12379643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12379643/
RECORD: Rec_0215189 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human red blood cells
4-128 μg/mL
Hemolysis
PMID12379643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12379643/
RECORD: Rec_0216117 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Hemolytic
Staphylococcus aureus
PMID16844081;18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16844081/
RECORD: Rec_0227856 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.2 μM
MIC
PaperG.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells Evidence URLhttps://www.uniprot.org/uniprotkb/P84936/entry
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