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MYP_104829
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Basic Information
Dermaseptin-5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C125H212N36O36
Standard
Sequence
GLWSTIKQKGKEAAIAAAKAAGQAALGAL
Physicochemical Analysis
2795.24 Da
10.00
2.76
2.55
0.0951
0.29
0.45
0.21
14.26
101.72
0.0345
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1161.93
-12.06
40.0
39.0
96.0
197.0
2.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0103660 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperG.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells Evidence URLhttps://www.uniprot.org/uniprotkb/P83637/entry
RECORD: Rec_0116449 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
6.42 μM
MIC
PMID12379643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12379643/
RECORD: Rec_0117593 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
3.20 μM
MIC
PMID12379643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12379643/
RECORD: Rec_0125301 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.2 μM
MIC
PaperG.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells Evidence URLhttps://www.uniprot.org/uniprotkb/P83637/entry
RECORD: Rec_0151397 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
6.42 μM
MIC
PaperG.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells Evidence URLhttps://www.uniprot.org/uniprotkb/P84600/entry
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