MYP_104626
Haloduracin
Anticancer
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Standard
28 amino acids
C130H202N36O40S6
Standard
CAWYNISCRLGNKGAYCTLTVECMPSCN
3101.60 Da
7.82
0.71
0.43
0.0254
0.11
0.52
0.10
109.53
59.29
0.1071
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1231.89
-14.26
48.0
47.0
96.0
212.0
5.0
30.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0136571
VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0320405
VERIFIED: YES
Provenance & Taxonomy
Bacillus halodurans [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
RECORD: Rec_0326499
VERIFIED: YES
Provenance & Taxonomy
Bacillus halodurans [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Identified by using bioinformatics. Displayed is the sequence of HalA1 (chain A) prior to modification. HalA2 (Chain b) has the sequence: GDVHAQTTWPCATVGVSVALCPTTKCTSQC Chemical modification: Three thioether rings are proposed in chain A: S7-C17, T18-C23, and T20-C27. In addition, two remaining Cys residues form a S-S bond. The sequence of HalA2 before modification is TTWPCATVGVSVALCPTTKCTSQC. Four thioether rings are proposed: T1-C5, S11-C15, T17-C20, and T21-C24. In addition, T2, T7, and S22 are dehydrated in HalA2. Recombinant production:bacteria:Escherichia coli: His-tagged recombinant peptides and their modifying enzymes were purified and co-incubated to achieve dehydration. Peptides were then released by cleaving with factor Xa. Synergy:AMPs: Both chains are required for antibacterial activity, implying synergy. Subsequently, this two-chain lantibiotics was also reported by a another group (Lawton EM et al., 2007 FEMS Microbiol Lett. 267: 64-71), also based on bioinformatics analysis of the bacterial genome
Bio-Activity Profile
Antimicrobial
Lactococcus lactis strains HP, AM2, 104, 497, MG1363), Listeria monocytogenes L028, Listeria innocua EL, Enterococcus faecium DPC1146, Enterococcus faecium DPC3675, Enterococcus faecalis EL, Escherichia coli EC101
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