Peptide Database

Peptide NameSLAY-screened peptide P4138

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC70H117N29O18

DescriptionStandard

        RIHRRSHLDHVLN
    

Molecular Weight1652.86 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)2.02

Net Charge (pH 7.4) 1.67

Charge Density (pH 7.0) 0.1556

GRAVY Index-1.12

Hydrophobic Moment 0.35

Boman Index-0.47

Instability Index96.58

Aliphatic Index 112.31

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 784.88

LogP -7.96

H-bond Donors 29.0

H-bond Acceptors 23.0

Rotatable Bonds 55.0

Heavy Atoms 117.0

Ring Count 3.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0099919 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/