Peptide Database

Peptide Namepeptide 13 (derived from OH-CM6)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC120H200N30O21

DescriptionStandard

        KFFKKLKKAVKKGFKKFAKV
    

Molecular Weight2399.06 Da

Isoelectric Point (pI)10.95

Net Charge (pH 7.0)9.75

Net Charge (pH 7.4) 9.53

Charge Density (pH 7.0) 0.4875

GRAVY Index-0.62

Hydrophobic Moment 0.85

Boman Index-0.27

Instability Index-23.95

Aliphatic Index 58.50

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 876.42

LogP -2.10

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 91.0

Heavy Atoms 171.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0119228 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyOH-CM6

Tax ID32630

Structure & Mods

Configlysine-tethered side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsThe Ⓚ (position: 15 and 19) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (15) and Ⓚ (19) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetmethicillin-resistant Staphylococcus aureus

Activity4 μg/mL

MethodMIC99.9

PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/

RECORD: Rec_0119552 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyOH-CM6

Tax ID32630

Structure & Mods

Configlysine-tethered side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsThe Ⓚ (position: 4 and 8) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (4) and Ⓚ (8) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetListeria monocytogenes

Activity2 μg/mL

MethodMIC99.9

PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/

RECORD: Rec_0121890 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyOH-CM6

Tax ID32630

Structure & Mods

Configlysine-tethered side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsThe Ⓚ (position: 12 and 19) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (12) and Ⓚ (19) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli

Activity8 μg/mL

MethodMIC99.9

PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/

RECORD: Rec_0122616 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyOH-CM6

Tax ID32630

Structure & Mods

Configlysine-tethered side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsThe Ⓚ (position: 5 and 12) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (5) and Ⓚ (12) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetmethicillin-resistant Staphylococcus aureus

Activity8 μg/mL

MethodMIC99.9

PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/

RECORD: Rec_0124820 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic

Targethuman red blood cells

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