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MYP_104496
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Basic Information
peptide 13 (derived from OH-CM6)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C120H200N30O21
Standard
Sequence
KFFKKLKKAVKKGFKKFAKV
Physicochemical Analysis
2399.06 Da
10.95
9.75
9.53
0.4875
-0.62
0.85
-0.27
-23.95
58.50
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
876.42
-2.10
31.0
31.0
91.0
171.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0345255 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
lysine-tethered side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 11 and 15) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (11) and Ⓚ (15) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
clinically isolated drug-resistant Escherichia coli
32 μg/mL
MIC99.9
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
RECORD: Rec_0348453 VERIFIED: YES
Provenance & Taxonomy
Ophiophagus hannah [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ML-35p
6.25 μg/mL
MIC
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0358492 VERIFIED: YES
Provenance & Taxonomy
Ophiophagus hannah [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PA 01
12.5 μg/mL
MIC
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0360229 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcuss aureus clinical strain 2
3.125 μg/mL
MIC
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0360635 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
lysine-tethered side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 12 and 19) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (12) and Ⓚ (19) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
clinically isolated drug-resistant Escherichia coli
16 μg/mL
MIC99.9
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
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