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MYP_104496
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Basic Information
peptide 13 (derived from OH-CM6)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C120H200N30O21
Standard
Sequence
KFFKKLKKAVKKGFKKFAKV
Physicochemical Analysis
2399.06 Da
10.95
9.75
9.53
0.4875
-0.62
0.85
-0.27
-23.95
58.50
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
876.42
-2.10
31.0
31.0
91.0
171.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0286038 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
benzyl/aryl-linker stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 12 and 16) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (12) and Ⓚ (16) are cross-linked by a 1,3-bismethylenebenzene spacer employing the N-alkylation
Bio-Activity Profile
Antimicrobial Antibacterial
methicillin-resistant Staphylococcus aureus
4 μg/mL
MIC99.9
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
RECORD: Rec_0286180 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
lysine-tethered side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 8 and 12) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (8) and Ⓚ (12) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
clinically isolated drug-resistant Escherichia coli
32 μg/mL
MIC99.9
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
RECORD: Rec_0288818 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
HaCaT cell lines
Cell viability assay
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0290039 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli clinical strain 6
3.125 μg/mL
MIC
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0291315 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
benzyl/aryl-linker stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 12 and 16) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (12) and Ⓚ (16) are cross-linked by a 1,3-bismethylenebenzene spacer employing the N-alkylation
Bio-Activity Profile
Hemolytic
red blood cells
320 μg/mL
Hemolysis
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
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