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MYP_104496
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Basic Information
peptide 13 (derived from OH-CM6)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C120H200N30O21
Standard
Sequence
KFFKKLKKAVKKGFKKFAKV
Physicochemical Analysis
2399.06 Da
10.95
9.75
9.53
0.4875
-0.62
0.85
-0.27
-23.95
58.50
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
876.42
-2.10
31.0
31.0
91.0
171.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0159642 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa clinical strain 1
12.5 μg/mL
MIC
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0165335 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
lysine-tethered side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 12 and 16) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (12) and Ⓚ (16) are cross-linked by a (E)-but-2-enyl space employing the N-alkylation reactionr
Bio-Activity Profile
Antimicrobial Antibacterial
clinically isolated drug-resistant Escherichia coli
32 μg/mL
MIC99.9
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
RECORD: Rec_0165784 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
benzyl/aryl-linker stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 12 and 16) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (12) and Ⓚ (16) are cross-linked by a 1,2-bismethylenebenzene spacer employing the N-alkylation
Bio-Activity Profile
Cytotoxic
HEK293T cell line
Cell survival
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
RECORD: Rec_0171676 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae ATCC 13883
6.25 μg/mL
MIC
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0171772 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
OH-CM6
32630
Structure & Mods
lysine-tethered side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓚ (position: 7 and 11) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (7) and Ⓚ (11) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Hemolytic
red blood cells
320 μg/mL
Hemolysis
PaperHong Li, Yuchen Hu, Qi Pu, Tong He, Qianyu Zhang, Wen Wu, Xuefeng Xia and Jinqiang Zhang. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020 Apr 23;63(8):4081-4089. Epub 2020 Apr 8. PMID32216308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32216308/
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