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MYP_104495
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
6 amino acids
C32H57N7O7
Standard
Sequence
KVLPVP
Physicochemical Analysis
651.84 Da
8.75
0.76
0.55
0.1265
0.85
0.39
0.33
90.48
161.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
217.26
0.32
6.0
8.0
17.0
46.0
2.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0270883 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive Nitric oxide-modulating
Angiotensin-converting enzyme (ACE)
IC50
PaperCharacterization of casein-derived peptide bioactivity: Differential effects on angiotensin-converting enzyme inhibition and cytokine and nitric oxide production | Adams, C. et al. | DOI: 10.3168/jds.2019-17976 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0296099 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperAnimal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation
RECORD: Rec_0305274 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
21.4 mmHg
SBP decrease
PaperIs the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?
RECORD: Rec_0318965 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
5 μM
IC50
PaperA new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides. PMID23194537 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23194537/
RECORD: Rec_0331298 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
5.0
IC50
PaperMaeno M., Yamamoto N., Takano T.. Identification of antihypertensive peptides from casein hydrolysate produced by proteinase from Lactobacillus helveticus. J.Dairy Sci., 73, 1316-1321.
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