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MYP_104495
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Basic Information
β-Casein(169-174)-derived peptide KVLPVP
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Standard
6 amino acids
C32H57N7O7
Standard
Sequence
KVLPVP
Physicochemical Analysis
651.84 Da
8.75
0.76
0.55
0.1265
0.85
0.39
0.33
90.48
161.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
217.26
0.32
6.0
8.0
17.0
46.0
2.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0270883 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
angiotensin-converting enzyme (ACE)
5 μM
IC50
PaperCharacterization of casein-derived peptide bioactivity: Differential effects on angiotensin-converting enzyme inhibition and cytokine and nitric oxide production | Adams, C. et al. | DOI: 10.3168/jds.2019-17976 PMID8880454;17506570 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0296099 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
9913
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
PaperAnimal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation PMID8880454
RECORD: Rec_0305274 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
Spontaneously hypertensive rat (SHR)
21.4 mmHg
SBP decrease
PaperIs the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities? PMID8880454
RECORD: Rec_0318965 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
angiotensin-converting enzyme (ACE)
5 μM
IC50
PaperA new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides. PMID8880454;23194537;17506570 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23194537/
RECORD: Rec_0331298 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
angiotensin-converting enzyme (ACE)
5 μM
IC50
PaperMaeno M., Yamamoto N., Takano T.. Identification of antihypertensive peptides from casein hydrolysate produced by proteinase from Lactobacillus helveticus. J.Dairy Sci., 73, 1316-1321. PMID8880454;17506570
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