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MYP_104495
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Basic Information
β-Casein(169-174)-derived peptide KVLPVP
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Standard
6 amino acids
C32H57N7O7
Standard
Sequence
KVLPVP
Physicochemical Analysis
651.84 Da
8.75
0.76
0.55
0.1265
0.85
0.39
0.33
90.48
161.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
217.26
0.32
6.0
8.0
17.0
46.0
2.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012786 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
angiotensin-converting enzyme (ACE)
5 μM
IC50
PaperHigh-Level Expression of Milk-Derived Antihypertensive Peptide in Escherichia coli and Its Bioactivity | Liu, D. et al. | DOI: 10.1021/jf0703248 PMID8880454;17506570 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0073092 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
angiotensin-converting enzyme (ACE)
5 μM
IC50
PMID8880454;17506570
RECORD: Rec_0152518 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
PaperBioactive Peptides: A Review PMID8880454
RECORD: Rec_0155795 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
spontaneously hypertensive rats (SHR)
32.2 mmHg
SBP decrease (oral 2 mg/kg)
PaperAntihypertensive peptides from food proteins: a review. PMID8880454;22249830 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22249830/
RECORD: Rec_0168472 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
4116
Structure & Mods
proteolytic linear peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Angiotensin-converting enzyme inhibition Antihypertensive Cardiovascular
spontaneously hypertensive rats (SHR)
32.2 mmHg
SBP decrease (oral 2 mg/kg)
PaperWhey Proteins as Source of Bioactive Peptides Against Hypertension PMID8880454
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