Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length173 amino acids

Chemical FormulaC854H1338N234O230S9

DescriptionStandard

        PTALPTAHEPMLLLAVTDFVANSAASVYFTAGALRRNISADTLPRRFPLQLRTKSLGVFSPQLQERYPDQPMELLLSARRQPLLRCRPDALHGALFGSAEAFVVLPNATRVPAFVLNIVSGWCCHGTGELCPACSSPGWAQGLPVPQVKRLETLLKFGLWLFGVPWANSECCP
    

Molecular Weight18851.77 Da

Isoelectric Point (pI)8.85

Net Charge (pH 7.0)4.17

Net Charge (pH 7.4) 3.84

Charge Density (pH 7.0) 0.0241

GRAVY Index0.17

Hydrophobic Moment 0.57

Boman Index0.13

Instability Index63.62

Aliphatic Index 94.22

Aromaticity 0.0867

Extinction Coeff. Reduced 24980.00

Extinction Coeff. Oxidized 25355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7247.60

LogP -71.62

H-bond Donors 255.0

H-bond Acceptors 246.0

Rotatable Bonds 585.0

Heavy Atoms 1327.0

Ring Count 40.0

Amide Bonds 184.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0047124 VERIFIED: NO

Provenance & Taxonomy

OrganismNyctibius grandis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria